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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
3 TEK related diseases
H00531
Venous malformations
hsa05323
Rheumatoid arthritis
600195
Venous malformations, multiple cutaneous and mucosal
Summary of query kinase
Query kinase
TIE1 (
P35590
),
reference kinase: TEK
(
Q02763
)
Kinase group
TK
Number of conformation types
4
Number of structural templates
5 (
Total 566 inhibitors
)
Number of TEK related diseases
3 (
H00531
hsa05323
600195
)
Number of allelic variants
4 (
R849W
R915H
Y897C
Y897S
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
1
3L8PA_0CE
(TEK)
TK
LY_333531
I
4
30
8
A
3L8PA_0CE
(TEK)
TK
LY_333531
I
4
30
8
4
30
8
B
1
2WQBA_QQ1
(TEK)
TK
QQ1
I
3
14
8
B
2WQBA_QQ1
(TEK)
TK
QQ1
I
3
14
8
3
14
8
E
2
2OSCA_MUH
(TEK)
TK
2osc
II
17
136
36
E
2OSCA_MUH
(TEK)
TK
2osc
II
17
136
36
17
136
36
E
2OO8X_RAJ
(TEK)
TK
RAJ
II
16
246
36
16
246
36
F
1
2P4IA_MR9
(TEK)
TK
2p4i
II
3
52
10
F
2P4IA_MR9
(TEK)
TK
2p4i
II
3
52
10
3
52
10