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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
Other AURKA 133
CMGC CDC2 4
Other CHUK 15
Other PLK1 53
TK SRC 270
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK-EICINKMLNHENVVKFYGHRRE-----GNIQYLFLEYCSGGELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHLRHPNILRLYGYFHD-----ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN--------------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---------
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIR-EISLLKELRHPNIVSLQDVLMQ-----DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
-W-EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLEL-STKNRER-WCH-EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCC---GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD---VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS----------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQREKMSMEISIHRSLAHQHVVGFHGFFED-----NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEV---KIGDFGLATKV--EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS--------------CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF---------
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PG-TM-SPEAFL-Q-EAQVMKKLRHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-----------VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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