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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK2 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC GSK3B 56
CMGC MAPK1 13
CAMK MAPKAPK2 64
AGC PDPK1 82
AGC PRKCA 339
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIR------EISLLKEL-RHPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR------EISLLKEL-NHPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALR------EICLLKEL-KHKNIVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPEN-I-KK------EICINKML-NHENVVKFYGHRRE-----GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR------------EIKILENLRGGPNIITLADIVKDP---VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--------------
---YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-T-LR------EIKILLRF-RHENIIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK-----TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL--------------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------R------EVELHWRASQCPHIVRIVDVYENLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE----TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI--------------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD-----DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS-PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG----NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF---
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV-ECTM-----VEKRVLALLDKPPFLTQLHSCFQT-----VDRLY--FVMEYVNGG--DLMYHIQ----QVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH---MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPPFD-GE----DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
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