|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
CMGC CDC2 4
TK KDR 834
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR----SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I
YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM-QDSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL--
|