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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TEK 203
CMGC CDK6 13
TK ITK 363
AGC PRKCQ 380
--IKFQDVIGEGNFGQVLKARIKKDGLRM-DAAIKRMK-EYAS-KDDHRDFA-G-ELEVLCKLG-H---HPNIINLLGACEH-----RGYLYLAIEYAPHGNLLDFLR---KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCD--------------------------DEVYDLMRQCWREKPYERPSFA-QILV---SL
--YECVAEIGEGAYGKVFKARDL--KNGGRFVALKRVRVQTGEEGM--PLSTIR-EVAVLRHL--ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEP-----------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-YSFQMALTS---VVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAY-SALSHPYF-
--LTFVQEIGSGQFGLVHLGYWL---NKD-KVAIKTIR-EGAM-SE--EDFI-E-EAEVMMKL--S---HPKLVQLYGVCLE-----QAPICLVFEFMEHGCLSDYLR---TQ---------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAS--------------------------THVYQIMNHCWKERPEDRPAFS-RLLRQL---
FI--LHKMLGKGSFGKVFLAEFK--KTNQ-FFAIKALKKDVVLMDD--DVECTMVEKRVLSLA-WE---HPFLTHMFCTFQT-----KENLFFVMEYLNGGDLMYHIQ--SCH-----------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNT---FCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQ---DEEELFHSIRMDNPFYPRWLE------------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLF-
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