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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
AGC AKT1 150
AGC AKT3 148
AGC PKN1 615
AGC PRKACA 44
AGC PRKCD 349
AGC PRKG1 375
AGC PRKX 49
AGC ROCK1 76
AGC ROCK2 92
-F-EYLKLLGKGTFGKVILVKEK-ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-R---HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF
FD--YLKLLGKGTFGKVILVREK-ASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-R---HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHIKITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLS----SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF
-F-KFLAVLGRGHFGKVLLSEFR-PSGELFAIKALKKGDIVARDEVESLMCEKRILAAV-TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSACVVLGLQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS----AEAIGIMRRLLRRNPER--RLGSSERDAEDVKKQPFF
-F-ERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV-N---FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK----RVKGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF
FI--FHKVLGKGSFGKVLLGELK-GRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE---NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN-IFGESRASTFCGTPDYIAPEILQ----GLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWIT----KESKDILEKLFEREPTK--RLG----VTGNIKIHPFF
-F-NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA-H---SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHS-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK--IGFGKKTWTFCGTPEYVAPEIIL----NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIA--KNAANLIKKLCRDNPSE--RLGNLKNGVKDIQKHKWF
FD--TLATVGTGTFGRVHLVKEK-TAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEV-S---HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLDRDGHIKLTDFGFAKK----LVDRTWTLCGTPEYLAPEVIQ----SKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLD----FHVKDLIKKLLVVDRTR--RLGNMKNGANDVKHHRWF
--YEVVKVIGRGAFGEVQLVRHK-STRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-N---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF
--YDVVKVIGRGAFGEVQLVRHK-ASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-N---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF
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