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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
AGC AKT1 150
AGC AKT3 148
CMGC CDC2 4
CMGC CDK2 4
-F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS---RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS---RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEDIKFPRTLS--------------------------SDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFF
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
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