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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK EGFR 712
TK LCK 245
TK TNK2 150
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKA--QLEKAGV--EHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-E--A-TS-PKANKEIL-DEAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR-EH-KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL-EKGERLPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF
-LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-Q--G-SM-SP--DAFL-AEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK-TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L--
L-RLLEKLGDGSFGVVRRGEWD-APSGKTVSVAVKCLK-PDVL-SQ-PEAMDDFI-REVNAMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLR-KH-QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP--QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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