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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK JAK2 849
TK JAK3 822
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-REIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP--AEVHELMKLCWAPSPQDRPSFSALGP---QL-
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