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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BRAF 203
CAMK CHEK1 9
TK CSF1R 582
TK KDR 834
Other PLK1 53
--ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTAPT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLH-II--------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-S-R--WSGSHQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP----KAMKRLMAECLKKKRDERPLFPQILA---SI
-W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMK-RAVDCP--ENI-KK-EICINKML-NHENVVKFYGHRR-EGNIQYLFLEYCSGGELFDRIEPDI----------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREF---HAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKE----KKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRW-Y
--LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-S-TAH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-M-N--DSNYIVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ----MAQPAFAP----KNIYSIMQACWALEPTHRPTFQQICSFL---
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E-GAT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-Y-K--DPDYVRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTT----PEMYQTMLDCWHGEPSQRPTFSELVEHL---
YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKS-LLLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFE-DNDFVFVVLELCRRRSLLELHKRRK----------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS-KKG---HSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETYLRIKK----NEYSIPKHIN--PVAASLIQKMLQTDPTARPTINELLNDEFF-
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