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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK4 6
TK LCK 245
CMGC MAPK8 26
AGC PDPK1 82
Other PLK1 53
TK SRC 270
TK TNK2 150
--FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLD--TETE---GV--PS-TAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
--ITMKHKLGGGQYGEVYEGVWK---KYSLTVAVKTLK-E--DTM----EV--EE-FL-K-EAAVMKEIK---HPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
--YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLE--SEEE---GV--PS-TAIR-EISLLKELR---HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-Y-EPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVP--NGGGGGGGL--PI-STVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
--LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-Q--GSM----SP--DA-FL-A-EANLMKQLQ---HQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
--YQNLKPIGSGAQGIVCAAYDA---ILERNVAIKKLSRP--FQNQ---TH--AK-RAYR-ELVLMKCVN---HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
-F-KFGKILGEGSFSTVVLAREL---ATSREYAIKILEKR--HIIK---EN--KVPYVTR-ERDVMSRLD---HPFFVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIF-QKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDA---DTKEVFAGKIVPKS--LLLK---PH--QR-EKMSMEISIHRSLA---HQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETY-LRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
-L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-P--GTM----SP--EA-FL-Q-EAQVMKKLR---HEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
-L-RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK-PDVLSQ----PEAMDD-FI-R-EVNAMHSLD---HRNLIRLYGVVL-------TPPMKMVTELAPLGSLLDRLR----KH-QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL-PQ-N--DDHYVMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP-----------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
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