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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
TK FGFR2 481
TK MET 1078
TK PTK2 422
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PSTAIREISLLKEL-N---HPNIVKLLDVIH-T-----ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EEFL-KEAAVMKEI-K---HPNLVQLLGVCT-R-----EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EHQLRREVEIQSHL-R---HPNILRLYGYFH-D-----ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PSTAIREISLLKEL-R---HPNIVSLQDVLM-Q-----DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PISTVREVALLRRL-EAFEHPNVVRLMDVCA-TSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT----EKDLSDLV-SEMEMMKMIGK---HKNIINLLGACT-Q-----DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RI-TD----IGEVSQFL-TEGIIMKDF-S---HPNVLSLLGICLRS-----EGSPLVVLPYMKHGDLRNFIR----NE---------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS----DSVREKFL-QEALTMRQF-D---HPHIVKLIGVIT-------ENPVWIIMELCTLGELRSFLQ----VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM----SP--EAFL-QEAQVMKKL-R---HEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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