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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC GSK3B 56
-FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETE---GVPSTAIREISLLKELN---HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEE---GVPSTAIREISLLKELR---HPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Y-EPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE---GMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
-YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDKRFK---NR------ELQIMRKLD---HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
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