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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK4 6
Other CHUK 15
CMGC CSNK2A1 39
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
CMGC MAPK14 24
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETE---GV--PSTAIREISLLKEL-N---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
-ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-EDTM----EV--EEFL-KEAAVMKEI-K---HPNLVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-----------DLSQVYELLEKDYRMERPEGCP------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---------
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEE---GV--PSTAIREISLLKEL-R---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPNGGGGGGGL--PISTVREVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---------
W-EMRERLGTGGFGNVCLYQHR----ELDLKIAIKSCRLELSTK---NR--ER-WCHEIQIMKKL-N---HANVVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD---VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRP---------------FL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
-YQLVRKLGRGKYSEVFEAINI----TNNEKVVVKILKPVKKKK---IK--R-----EIKILENLRG---GPNIITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF---------
-YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFK---NR--------ELQIMRKL-D---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE-----EHLRDFE-REIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELLKNNGRLPRPDGCP------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP----DQ-QRDFQ-REIQILKAL-H---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV---KIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELLEEGQRLPAPPACP------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL--------
-YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPFQSI---IH--AKRTYRELRLLKHM-K---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-PGTM----SP--EAFL-QEAQVMKKL-R---HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-----------VNREVLDQVERGYRMPCPPECP------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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