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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK5 203
TK ABL1 261
Other AURKA 133
TK JAK2 849
TK LCK 245
CMGC MAPK14 24
YEKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDD-DDEGV--PSSALREICLLKELKHKNIVRLHDVLH--S------DKKLTLVFEFCDQ-DLKKYFDSCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-ED-TM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR--ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGIDLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHLRHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ-KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ--KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-QG-SM-SP--DAFL-AEANLMKQLQHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK--TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPF-QSIIH--AKRTYRELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK--CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
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