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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK6 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC GSK3B 56
TK JAK2 849
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
----YECVAEIGEGAYGKVFKARDL----KNGGRFVALKRVRVQTGEE---GM--PLSTIREVAVLRHL-ETFEHPNVVRLFDVCT--VSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP--GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI-----YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF--
----YTKIEKIGEGTYGVVYKGRHK----TTGQ-VVAMKKIRLESEEE---GV--PSTAIREISLLKEL-R---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
----FQKVEKIGEGTYGVVYKARNK----LTGE-VVALKKIRLDTETE---GV--PSTAIREISLLKEL-N---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---Y-EPVAEIGVGAYGTVYKARDP----HSGH-FVALKSVRVPNGGGGGGGL--PISTVREVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP--GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
---W-DLVQTLGEGAYGEVQLAVNR----VTEE-AVAVKIVDMKRAVD---CP--ENI-KKEICINKML-N---HENVVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
----YQLVRKLGRGKYSEVFEAINI----TNNE-KVVVKILKPVKKKK---IK--R-----EIKILENLRG---GPNIITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF--
----YTDTKVIGNGSFGVVYQAKLC----DSGE-LVAIKKVLQDKRFK---NR--------ELQIMRKL-D---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
----LKFLQQLGKGNFGSVEMCRYDPLQDNTGE-VVAVKKLQ-HSTE-----EHLRDFE-REIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QMIVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
----YQNLKPIGSGAQGIVCAAYDA----VLDR-NVAIKKLSRPFQNQ---TH--AKRAYRELVLMKCV-N---HKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI--
-LQG---LRPVGSGAYGSVCSAYDA----RLRQ-KVAVKKLSRPFQSL---IH--ARRTYRELRLLKHL-K---HENVIGLLDVFT--PATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ--ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR-------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKAL---------------FP-GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF--
----YRDLQPVGSGAYGAVCSAVDG----RTGA-KVAIKKLYRPFQSE---LF--AKRAYRELRLLKHM-R---HENVIGLLDVFT--PDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE--KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR-------QADSEMTG---YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTL---------------FK-GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF--
YVSP----THVGSGAYGSVCSAIDK----RSGE-KVAIKKLSRPFQSE---IF--AKRAYRELLLLKHM-Q---HENVIGLLDVFT--PASSLRNFYDFY--LVMPFMQT---DLQKIM------GM--EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR-------HADAEMTG---YVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTL---------------FK-GKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP-----------RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF--
----YQNLSPVGSGAYGSVCAAFDT----KTGL-RVAVKKLSRPFQSI---IH--AKRTYRELRLLKHM-K---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
----YQNLKPIGSGAQGIVCAAYDA----ILER-NVAIKKLSRPFQNQ---TH--AKRAYRELVLMKCV-N---HKNIIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
----YQQLKPIGSGAQGIVCAAFDT----VLGI-NVAVKKLSRPFQNQ---TH--AKRAYRELVLLKCV-N---HKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIH------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVI---------------FQ-GTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI--
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