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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CLK1 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC GSK3B 56
CMGC MAPK1 13
CAMK MAPKAPK2 64
---YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS---------EIQVLEHL-NTTDPNSTFRCVQMLEWFEH-----HGHIC--IVFELLGL---STYDFIK----ENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFV-QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA------TYDDEHHSTLVSTRHYRAPEVIL---ALGWSQPCDVWSIGCILIEYYL-GFTVFP-TH-DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
---YTKIEKIGEGTYGVVYKGRHKTT-GQVVAMKKIRLESEEEGVPSTAIR------EISLLKEL-R--HPN----IVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---FQKVEKIGEGTYGVVYKARNKLT-GEVVALKKIRLDTETEGVPSTAIR------EISLLKEL-N--HPN----IVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YEKLEKIGEGTYGTVFKAKNRET-HEIVALKRVRLDDDDEGVPSSALR------EICLLKEL-K--HKN----IVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
-YI--MSKTLGSGACGEVKLAFERKT-CKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-N--HPC----IIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNKRL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC----------------LIKITDFGHSKI----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL
---YQLVRKLGRGKYSEVFEAINITN-NEKVVVKILKPVKKKKIKR-----------EIKILENLRG--GPN----IITLADIVKDP---VSRTPA--LVFEHVNNT--DFKQLY-------QTL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL-------------------RLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
---YTDTKVIGNGSFGVVYQAKLCDS-GELVAIKKVLQDKRFKNR------------ELQIMRKL-D--HCN----IVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
---YTNLSYIGEGAYGMVCSAYDNVN-KVRVAIKKISPFEHQTYCQRT-LR------EIKILLRF-R--HEN----IIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK-----TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL-------------------KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
KVT---SQVLGLGINGKVLQIFNKRT-QEKFALKMLQDCPKAR-------R------EVELHWRASQ--CPH----IVRIVDVYENLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAF--TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNA----------------ILKLTDFGFAKE----TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-------------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI
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