|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CSNK2A1 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
YQLVRKLGRGKYSEVFEAINITNNE-KVVVKILKPVKKKKIKR-----EIKILENLRG---GPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEEGVPSTAIREISLLKEL-R---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETEGVPSTAIREISLLKEL-N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDEGVPSSALREICLLKEL-K---HKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL-ETFEHPNVVRLFDVCTVSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI-YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDKRFKNR------ELQIMRKL-D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
YQNLKPIGSGAQGIVCAAYDAVLDR-NVAIKKLSRPFQNQTHAKRAYRELVLMKCV-N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
YQNLSPVGSGAYGSVCAAFDTKTGL-RVAVKKLSRPFQSIIHAKRTYRELRLLKHM-K---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
|