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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK EPHA3 621
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK KIT 589
TK LCK 245
STE OXSR1 17
AGC PDPK1 82
TK PTK2B 425
TK RET 724
AGC RPS6KA1 62
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
---F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANKE-IL-DEAYVMASV-DNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR---------EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT---------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF---------
----ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--EE-FL-KEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR---------EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP---------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDELD-FL-MEALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR---------ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFV-TSGGRMDPPKNCP---------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I-----------
----FEIGRPLGKGKFGNV---YLAREK-------QSKFILALKVLFKA--QLEKAGV--EH-QLRREVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ--------KLS-----------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV---------HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT-------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---I-SIDKVVGAGEFGEV---CSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRRD-FL-GEASIMGQF-DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR---------KH---------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL---E---D--DPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAV-DEGYRLPPPMDCP---------AALYQLMLDCWQKDRNNRPK-----FEQIVSIL-------------
---L-RKLKVLGSGVFGTV---HKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQA-VT-DHMLAIGSL-DHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVR---------QH---------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL---P---P--DDKQ-LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLL-EKGERLAQPQICT---------IDVYMVMVKCWMIDENIRPT-----FKELANE--F-----------
---L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLSD-LI-SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ---------ARRPPGLEY------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT---------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLSD-LV-SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLR---------ARRPPGMEY------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---N---N--IDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT---------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
----LKLEKKLGAGQFGEV---WMATYN--------KHTKVAVKTMK-P--G-SM-SV--EA-FL-AEANVMKTL-QHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLK---------SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP---------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERIE-FL-NEASVMKEF-NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLR---------SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP---------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I-----------
----ITLLRELGQGSFGMV---YEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERIE-FL-NEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLR---------SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y---E--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP---------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL-------------
----LSFGKTLGAGAFGKV---VEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTEREA-LM-SELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLR---------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K---N--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP---------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I-----------
----LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--DA-FL-AEANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK---------TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP---------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
----YELQEVIGSGATAVV---QAAYCA-------PKKEKVAIKRINLE--K-CQTSM--DE--LLKEIQAMSQC-HHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG-----------------------------------------------------------------------------VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLAT--GGDITRNKVR-KT---FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKY-PPMKVLMLT-LQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPT-----AAELLRHKFF-----------
---F-KFGKILGEGSFSTV---VLAREL-------ATSREYAIKILEKR--H-IIKEN--KVPYVTRERDVMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR--------KIG-----------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS-----PESKQARA-NS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG----NEYLIF-QKIIKLEYDFPEKFF-------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---V-VLNRILGEGFFGEV---YEGVYT----NHKGEKINVAVKTCK-K--D-CT-LDNKEK-FM-SEAVIMKNL-DHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYLE---------RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVL-EKGDRLPKPDLCP---------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L-----------
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELRD-LL-SEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLR---------ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS---------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKA--T-LKVRD--RV-RTKMERDILADV-NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLS--------KEV-----------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEA-------IDHEKKA-YS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK----DRKETM-TLILKAKLGMPQFLS-------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-P--G-TM-SP--EA-FL-QEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK---------GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
----FTKLEKIGKGSFGEV---FKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--ED-IQ-QEITVLSQC-DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE---------PG-----------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKVLFLI-PKNNPPTLEGNYS---------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
---L-RLLEKLGDGSFGVV---RRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMDD-FI-REVNAMHSL-DHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLR---------KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ---N--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP---------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L-----------
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTEE-MM-REAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLV---------GK---------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP---------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M-----------
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