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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other EIF2AK2 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK DAPK1 13
AGC GRK6 186
CMGC GSK3B 56
TK LCK 245
CAMK MAPKAPK2 64
AGC PDPK1 82
Other PLK1 53
TK PTK2B 425
STE STK24 24
TK ZAP70 338
---F-KEIELIGSGGFGQVFKAKHR---IDGKTYVIKRVKYNN-EKAER-------------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE---KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-------LKNDGKRTR---SKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VCDTAFET--------SKFFTDLRDGIISDIFDK------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT--------
----FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKAGV--EH-QLRR----EVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN----TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
----FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDT-ETEGV--PS-TAIR----EISLLKEL-NHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
----YEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMEN-EKEGF--PI-TALR----EIKILQLL-KHENVVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RS-PIMQGN-TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
----YDTGEELGSGQFAVVKKCREK---STGLQYAAKFIKKRR-TKSSR--RG-VSREDIEREVSILKEI-QHPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKE---SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-------IDFGNEFKN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GA-SPFLGD----TKQETLANVSAVNYEFEDEYFSNTS-------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
---F-RQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKR-IKKRK--GE-AMAL---NEKQILEKV-NSRFVVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLKFHIYH--MGQA---GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH-------VPEGQTIKG---RVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIA-GQ-SPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS-------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
----YTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
----LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-QG-SM-SP--DA-FL-A----EANLMKQL-QHQRLVRLYAVVT------------------------------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC----KIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
-KVT---SQVLGLGINGKVLQIFNK---RTQEKFALKMLQDCP-KAR----------R----EVELHWRASQCPHIVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ---AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE-------TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GY-PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-----------
---F-KFGKILGEGSFSTVVLAREL---ATSREYAIKILEKRH-IIKEN--KVPYVTR----ERDVMSRL-DHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS----PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG----NEYLIFQKIIKLEYDFPEKFF-----------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
--YV--RGRFLGKGGFAKCFEISDA---DTKEVFAGKIVPKSL-LLKPH--QR-EKMS---MEISIHRSL-AHQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV------EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GK-PPFETS----CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
---V-VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCK-KD-CT-LDNKEK-FM-S----EAVIMKNL-DHPHIVKLIGIIE------------------------------EEPTW--IIMELYPYG--ELGHYLE-----RN-KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-SPECV----KLGDFGLSRYI------E--DEDYYKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGK-QPFFWL-ENKDVIGVLEKGDRLPKPDLCP-------------------------------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L-----------
----FTKLEKIGKGSFGEVFKGIDN---RTQKVVAIKIIDLEE-AEDEI--ED-IQ-Q----EITVLSQC-DSPYVTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SALDLLE-----PG---PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL------TDTQIKRNT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GE-PPHSEL-HPMKVLFLIPKNNPPTLEGNYS-------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
LIAD----IELGCGNFGSVRQGVYR-MRKKQIDVAIKVLK-QG-TE-KADTEE-MM-R----EAQIMHQL-DNPYIVRLIGVCQ------------------------------AEALM--LVMEMAGGG--PLHKFLV-----GK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYA----KISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKM-KGPEVMAFIEQGKRMECPPECP-------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M-----------
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