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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB4 203
TK ALK 1116
TKL BRAF 456
TK EGFR 712
TK FYN 271
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK JAK1 875
TK JAK2 849
TK KDR 834
TK SRC 270
TK TEK 824
--V-KIEEVIGAGEFGEVCRGRLK--APGKKESCVAIKTLK-G-GYT-ERQRR-EFL-S-EASIMGQF-EHPNIIRLEGVVT--NSMP--VMILTEFMENGALDSFLR----LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENS-S--DPTYTSSLGGKIPIRWTAPEAIAFRK---FTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAIEQDYR----LPPPPDCP--------------TSLHQLMLDCWQKDRNARPRFPQVVSAL----
--I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-E-VCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSL--QSLP--RFILLELMAGGDLKSFLR----ETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y-R--ASYYRKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGR----MDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER-I---
---ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTAPT-PQQLQ-AFK-N-EVGVLRKT-RHVNILLFMGYST---KPQ--LAIVTQWCEGSSLYHHLH----II-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---S-R--WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP--------------KAMKRLMAECLKKKRDERPLFPQILA--SI--
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E-ATS-PKANK-EIL-D-EAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVR----EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G-A--EEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICT--------------IDVYMIMVKCWMIDADSRPKFRELI---IEF-
---LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLK-P-GTM-SP--E-SFL-E-EAQIMKKL-KHDKLVQLYAVVS---EEP--IYIVTEYMNKGSLLDFLK----DG----------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYR----MPCPQDCP--------------ISLHELMIHCWKKDPEERPTFEYLQSFL----
---ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-E-AAS-MRERI-EFL-N-EASVMKEF-NCHHVVRLLGVVS--QGQP--TLVIMELMTRGDLKSYLR----SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y-E--TDYYRKGGKGLLPVRWMSPESLKDGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGL----LDKPDNCP--------------DMLFELMRMCWQYNPKMRPSFLEIISS-I---
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-E-SAS-LRERI-EFL-N-EASVMKGF-TCHHVVRLLGVVS--KGQP--TLVVMELMAHGDLKSYLR----SLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y-E--TDYYRKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGY----LDQPDNCP--------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAM-VDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSS--DGDD--LCLVYVYMPNGSLLDRLSCLDGTP-------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE---KFAQTVMTSR---IVGTTAYMAPEALR-GE---ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-REPQLLLDIKEEIE----DEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ---LLQ
--L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSLK-P-ESG-GNHIA-DLK-K-EIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP----KN-----------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVES---EHQVKIGDFGLTKAI--ET-D--KEYYTVKDDRDSPVFWYAPECLMQSK---FYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKR----LPCPPNCP--------------DEVYQLMRKCWEFQPSNRTSFQNLIE--GF--
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H-STE--EHLR-DFE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ----KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ-D--KEYYKVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP--------------DEIYMIMTECWNNNVNQRPSFRDLA---LRV-
---LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E-GAT-HSEHR-ALM-S-ELKILIHIGHHLNVVNLLGACT-KPGGP--LMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI---Y-K--DPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTR----MRAPDYTT--------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
--L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-P-GTM-SP--E-AFL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEP--IYIVTEYMSKGSLLDFLK----GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYR----MPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAF-L---
---IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMK-E-YAS-KDDHR-DFA-G-ELEVLCKLGHHPNIINLLGACE--HRGY--LYLAIEYAPHGNLLDFLR----KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ---------EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKLPQGYR----LEKPLNCD--------------DEVYDLMRQCWREKPYERPSFAQILV--SL--
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