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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR2 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
TK EGFR 712
TK EPHA2 613
TK ERBB3 709
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK4 186
TK LCK 245
TK MERTK 587
TK MET 1078
TK MST1R 1082
Other NEK7 34
AGC PDPK1 82
Other PLK1 53
Other PLK4 12
TK PTK2 422
TK PTK2B 425
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S-EMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLR-----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI--N-N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K-EAAVMKEI-KHPNLVQLLGVCT-REPP-----FYIITEFMTYGNLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-D-FL-M-EALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR-----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV-TSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR-EVEIQSHL-RHPNILRLYGYFH-DATR-----VYLILEYAPLGTVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR-EISLLKEL-NHPNIVKLLDVIH-TENK-----LYLVFEFLHQ-DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-E-IL-D-EAYVMASV-DNPHVCRLLGICL--TST-----VQLITQLMPFGCLLDYVR-----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL-EKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
---V-TRQKVIGAGEFGEVYKGMLKT---SSGKKEVPVAIKTLK-A--G-YT-EKQRV-D-FL-G-EAGIMGQF-SHHNIIRLEGVIS-KYKP-----MMIITEYMENGALDKFLR-----EK-----------------------DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVL--E-D--DPEA-TYTTSGGKIPIRWTAPEAIS-YRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCP----------------------------SAIYQLMMQCWQQERARRPKFADIVSIL-------------
---L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-A-VT-D-HMLAIGSL-DHAHIVRLLGLCP--GSS-----LQLVTQYLPLGSLLDHVR-----QH-----------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS---PSQVQVADFGVADLL--P-P--DDKQ--LLYSEAKTPIKWMALESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLL-EKGERLAQPQICT----------------------------IDVYMVMVKCWMIDENIRPTFKELANE--F-----------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S-EMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLQ-----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL-KEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A-EANVMKTL-QHDKLVKLHAVVT--KEP-----IYIITEFMAKGSLLDFLK-----SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-E-FL-N-EASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLR-----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-E-FL-N-EASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR-----SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI--Y-E--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFDQEIKVMAKC-QHENLVELLGFSS-DGDD-----LCLVYVYMPNGSLLDRLSC-LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A-EANLMKQL-QHQRLVRLYAVVT--QEP-----IYIITEYMENGSLVDFLK-----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLD--N-SS-QREIE-E-FL-S-EAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL-----YSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI--Y-S--GDYY--RQGRIAKMPVKWIAIESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL-LHGHRLKQPEDCL----------------------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L-----------
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T-EGIIMKDF-SHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLRNFIR-----NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
-THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-R--I-TE-MQQVE-A-FL-R-EGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR-----SP-----------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI--L-D--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFL-AQGRRLPQPEYCP----------------------------DSLYQVMQQCWEADPAVRPTFRVLV----GEV---------
----FRIEKKIGRGQFSEVYRAACL-------LDGVPVALKKVQIF--D-LMDAK--A-R-ADCIKEIDLLKQL-NHPNVIKYYASFI-EDNE-----LNIVLELADAGDLSRMIKHFKKQKR-------------------------LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITA---TGVVKLGDLGLGRFF----SSKTTAA--HS---LVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD-KMNLYSLC-KKIEQCDYPPLPSDHYS------------------------EELRQLVNMCINPDPEKRPDVTYV------YDVA-------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR-ERDVMSRL-DHPFFVKLYFTFQ-DDEK-----LYFGLSYAKNGELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS--PESKQARA--NS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIF-QKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMSMEISIHRSL-AHQHVVGFHGFFE-DNDF-----VFVVLELCRRRSLLELHK----RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE---DLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETY-LRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
---F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKK--A-MYKAG--M-V-QRVQNEVKIHCQL-KHPSILELYNYFE-DSNY-----VYLVLEMCHNGEMNRYLK---NRVK-------------------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---NMNIKIADFGLATQL----KMPHEKH--YT---LCGTPNYISPEIAT-RSAHGLESDVWSLGCMFYTLLI-GRPPFDTD---TVKNTL-NKVVLADYEMPSFLS--------------------------IEAKDLIHQLLRRNPADRLSLSSVLDHPFM-----------
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q-EALTMRQF-DHPHIVKLIGVIT--ENP-----VWIIMELCTLGELRSFLQ-----VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI-ENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K--D-CT-LDNKE-K-FM-S-EAVIMKNL-DHPHIVKLIGIIE--EEP-----TWIIMELYPYGELGHYLE-----RN-----------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI----E--DEDY--YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVL-EKGDRLPKPDLCP----------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L-----------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S-EFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q-EAQVMKKL-RHEKLVQLYAVVS--EEP-----IYIVTEYMSKGSLLDFLK-----GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q-EITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLE-----PG-------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL----TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLI-PKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R-EVNAMHSL-DHRNLIRLYGVVL--TPP-----MKMVTELAPLGSLLDRLR-----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL-PQ-N--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R-EAQIMHQL-DNPYIVRLIGVCQ--AEA-----LMLVMEMAGGGPLHKFLV-----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M-----------
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