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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL IRAK4 203
TK FGFR1 478
TKL IRAK1 212
TK ITK 363
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMVDITTE--ELKQQFD-QEIKVMAKC-QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLDEAFTAKISDFGLARASE--------KFAQTVMTSR---IVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT-GLPAVDEH--REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ--LLQ
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLS-DLI-S--EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLARDI----H-----H--IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV--PVEELFKLLKEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
FSEE----LKIGEGGFGCVYRAVMR-------NTV--YAVKRLKENADLEWT--A-VKQSFLTEVEQLSRF-RHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACP-----------------PLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAG-SSPSQSSMVARTQT---VRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLA-GQRAVKTHGAR-TKYLKDLVEEEAEEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYE--RL-
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EGAM-SE--E-DFI-E--EAEVMMKL-SHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVGENQVIKVSDFGMTRFV----------L--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENR--SNSEVVEDISTGFRLYKPRLAS-------------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
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