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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL IRAK4 203
TK ABL1 261
Other AURKA 133
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK LCK 245
STE MAP2K1 68
TK MET 1078
AGC PDPK1 82
Other PLK1 53
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-----QEIKVMAKC-QHENLVELLGFSS-D--------GDDLCLVYVYMPNGSLLDRLSCLDGTP-------------------------PLSWHMRCKIAQGAANGINFLHE-NHHIHRDIKSANILLDEAFTA---KISDFGLARASE----KFAQTVMT--SR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K------EAAVMKEI-KHPNLVQLLGVCT-R--------EPPFYIITEFMTYGNLLDYLR----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVGENHLV---KVADFGLSRLM------T--GDTY--TAHAGAKFPIKWTAPESLA---YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR------EVEIQSHL-RHPNILRLYGYFH-D--------ATRVYLILEYAPLGTVYRELQ---KLS-------------------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGEL---KIADFGWSV--------HAPSSRR--TT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR------EISLLKEL-NHPNIVKLLDVIH-T--------ENKLYLVFEFLHQ-DLKKFMDA-SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLINTEGAI---KLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
---YEKLAKIGQGTFGEVFKARHR-------KTGQKVALKKVLME--N-EKEGF--P-I-TALR------EIKILQLL-KHENVVNLIEICR-TKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLITRDGVL---KLADFGLARAFSL--AKNSQPNRY--TN---RVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF-----------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKR--K-FAIGS--A-R-EADPALNVETEIEILKKL-NHPCIIKIKNFF--D--------AEDYYIVLELMEGGELFDKVV---GNK-------------------------RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-------LGETSLM--RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-----------
--L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCIKVIE-D--K-SG-RQSFQ-A-VT-D------HMLAIGSL-DHAHIVRLLGLCP----------GSSLQLVTQYLPLGSLLDHVR----QH-----------------------RGALGPQLLLNWGVQIAKGMYYLEE-HGMVHRNLAARNVLLKSPSQV---QVADFGVADLL---P--P--DDKQ--LLYSEAKTPIKWMALESIH---FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLL-EKGERLAQPQICT-------------------------------------------IDVYMVMVKCWMIDENIRPTFKELANE--F-----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S------EMEMMKMIGKHKNIINLLGACT-Q--------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-KKCIHRDLAARNVLVTEDNVM---KIADFGLARDI---H--H--IDYY--KKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL-KEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S------EMEMMKMIGKHKNIINLLGACT-Q--------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-QKCIHRDLAARNVLVTENNVM---KIADFGLARDI---N--N--IDYY--KKTTNGRLPVKWMAPEALF---DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A------EANVMKTL-QHDKLVKLHAVVT----------KEPIYIITEFMAKGSLLDFLK----SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVSASLVC---KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN---FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCP-------------------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERI-E-FL-N------EASVMKEF-NCHHVVRLLGVVS-Q--------GQPTLVIMELMTRGDLKSYLR----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-NKFVHRDLAARNCMVAEDFTV---KIGDFGMTRDI---Y--E--TDYY--RKGGKGLLPVRWMSPESLK---DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCP-------------------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERI-E-FL-N------EASVMKGF-TCHHVVRLLGVVS-K--------GQPTLVVMELMAHGDLKSYLR----SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-KKFVHRDLAARNCMVAHDFTV---KIGDFGMTRDI---Y--E--TDYY--RKGGKGLLPVRWMAPESLK---DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDQPDNCP-------------------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-------------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A------EANLMKQL-QHQRLVRLYAVVT----------QEPIYIITEYMENGSLVDFLK----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVSDTLSC---KIADFGLARLI------E--DNEY--TAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
---FEKISELGAGNGGVVFKVSHK-------PSGL-VMARKLIHL--E-IKPAI--R-N-QIIR------ELQVLHEC-NSPYIVGFYGAFY-S--------DGEISICMEHMDGGSLDQVLK---KAG-------------------------RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI---KLCDFGVSG--------QLIDSMA--NS---FVGTRSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-----------
---VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T------EGIIMKDF-SHPNVLSLLGICLRS--------EGSPLVVLPYMKHGDLRNFIR----NE-----------------------THNPTVKDLIGFGLQVAKGMKYLAS-KKFVHRDLAARNCMLDEKFTV---KVADFGLARDM---Y--D--KEYYSVHNKTGAKLPVKWMALESLQ---TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR------ERDVMSRL-DHPFFVKLYFTFQ-D--------DEKLYFGLSYAKNGELLKYIR---KIG-------------------------SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHI---QITDFGTAKVLS----PESKQARA--NS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-----MEISIHRSL-AHQHVVGFHGFFE-D--------NDFVFVVLELCRRRSLLELHK---RRK-------------------------ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLNEDLEV---KIGDFGLATKV------EYDGERK--KT---LCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S------EFNVLKQV-NHPHVIKLYGACS-Q--------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVAEGRKM---KISDFGLSRDV---Y--E--EDSY--VKRSQGRIPVKWMAIESLF---DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL-KTGHRMERPDNCS-------------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q------EAQVMKKL-RHEKLVQLYAVVS----------EEPIYIVTEYMSKGSLLDFLK----GE----------------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVC---KVADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
---FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q------EITVLSQC-DSPYVTKYYGSYL-K--------DTKLWIIMEYLGGGSALDLLE----PG-------------------------PLDETQIATILREILKGLDYLHS-EKKIHRDIKAANVLLSEHGEV---KLADFGVAGQL------TDTQIKR--NT---FVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLI-PKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI-----------
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R------EVNAMHSL-DHRNLIRLYGVVL----------TPPMKMVTELAPLGSLLDRLR----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLATRDLV---KIGDFGLMRAL--PQ--N--DDHY--VMQEHRKVPFAWCAPESLK---TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-----------
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