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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
TK ABL1 261
TKL BRAF 456
TK EGFR 712
TK JAK1 875
TK JAK3 822
TK LCK 245
TK RET 724
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQH-STE-EHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQKH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEIKHPNLVQLLGVCT--REPP--FYIITEFMTYGNLLDYLREC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYST---KPQ--LAIVTQWCEGSSLYHHLHII-----------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELRE-ATSPKANKEILDEAYVMASVDNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVREH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GAEEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGER----LPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSLKP-ESGGNHIADLKKEIEILRNLYHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLPKN-----------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSK---FYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKR----LPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE--GF-
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQH-SGPDQ-QRDFQREIQILKALHSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQRH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQR----LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP--QL-
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQLQHQRLVRLYAVVT---QEP--IYIITEYMENGSLVDFLKTP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKE-NASPSELRDLLSEFNVLKQVNHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSYVKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHR----MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
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