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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK2 203
Other AURKA 133
Other AURKB 77
TK IGF1R 999
LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KH---------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV
FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQKSC-----------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA---SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV--
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRERIEFL-N-EASVMKEFNCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR-SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGLSNEQVLRFVMEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I--
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