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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ALK 1116
Other AURKA 133
CMGC CDC2 4
TK CSK 195
TK IGF1R 999
CMGC MAPK14 24
AGC PRKCB 342
TK SRC 270
TK SYK 371
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLK----TP--------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
---I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EV-CS-EQD-ELDFL-M-EALIISKF-NHQNIVRCIGVSL-Q------SLPRFILLELMAGGDLKSFLR----ETRP---RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--------------
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFH-D------ATRVYLILEYAPLGTVYRELQ---KLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL-RHPNIVSLQDVLM-Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
----LKLLQTIGKGEFGDVMLGDYR-------GNKVAVKCIK-ND-AT-AQ----AFL-A-EASVMTQL-RHSNLVQLLGVIVEE------KGGLYIVTEYMAKGSLVDYLR----SR--------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA--------S-STQDTGKLPVKWTAPEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP------------------------------PAVYEVMKNCWHLDAAMRPSFLQLREQL----------------
----ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRE-RIEFL-N-EASVMKEF-NCHHVVRLLGVVS-Q------GQPTLVIMELMTRGDLKSYLR----SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--------------
----YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPF-QSIIH---AKRTYR-ELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
---F-NFLMVLGKGSFGKVMLSERK-----GTDELYAVKILKKDV-VIQDD---DVECTMVEKRVLALPGKPPFLTQLHSCFQ-T------MDRLYFVMEYVNGGDLMYHIQ---QVG-----------RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDS---EGHIKIADFGMCKEN--IWDGVTT-KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE---DEDELFQSIMEHNVAYPKSMS----------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
---L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS--------EEPIYIVTEYMSKGSLLDFLK----GE--------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--------------
-TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE--------AESWMLVMEMAELGPLNKYLQ----QN----------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL------------
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-QG-TE-KAD-TEEMM-R-EAQIMHQL-DNPYIVRLIGVCQ--------AEALMLVMEMAGGGPLHKFLV----GK---------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--------------
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