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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
CMGC CDK2 4
TK HCK 241
TK SRC 270
-LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK---TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-LKLEKKLGAGQFGEVWMATYN-KHTKVAVKTMK-PGSM-SVEAFL-AEANVMKTLQHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLK---SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L
L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK---GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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