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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK1 203
CMGC CDC2 4
CMGC CDK2 4
TK EPHB4 615
CMGC GSK3A 119
TK LCK 245
-YTNLSYIGEGAYGMVCSAYDN---VNKVRVAIKKISPFEHQTYC--QRT-LREIKILLRFRHENIIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
-YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKELRHPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
V-KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYT-ERQRREFL-SEASIMGQFEHPNIIRLEGVVTN-----SMPVM--ILTEFMENG--ALDSFLR----LN-DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEENS--S--DPTYTSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP------------------------------TSLHQLMLDCWQKDRNARPRFPQVVSAL--
-YTDIKVIGNGSFGVVYQARLA---ETRELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT--KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
-LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQLQHQRLVRLYAVVT------QEPIY--IITEYMENG--SLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
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