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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
CMGC CDK2 4
CMGC CDK5 4
CMGC GSK3B 56
TK LCK 245
AGC PRKACA 44
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKHKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF
-LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-A-EANLMKQLQHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAK---RVKGRTWT---LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD---QPIQIYEKIVSGKVRFPSHFS----------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
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