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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK8 203
Other AURKA 133
CAMK CHEK2 220
CAMK MAPKAPK2 64
---YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQTHAKRAYR------ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVCHKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR------EVEIQSHL-RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ--KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV-HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAREADPALNVETEIEILKKL-NHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR-------R------EVELHWRASQCPHIVRIVDVYENLY--AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI
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