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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
CMGC CDK2 4
TK CSF1R 582
TK EGFR 712
TK INSR 1023
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KDR 834
TK RET 724
TK TNK2 150
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLN-R--ITD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIR---NE--------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-YD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYL-LQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I--
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLD--TETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALT----------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-S--TAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY--IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLV-KDGYQMAQPAFAP----------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E--ATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-E--SAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR---SLRPEA-----------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFV-MDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
-LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-E--GAM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQY--TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDI-STGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H--STE--EHLRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-H--SGP-DQ-QRDFQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYY--VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E--GAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR---SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YK--DPDY--VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRL-KEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-E--NAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YE--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL----
L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVLSQ-PEAMDDFI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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