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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
TK JAK2 849
TK KDR 834
TK RET 724
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIRNE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-YDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I--
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQHSTE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY--KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YKDPDY--VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
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