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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MST1R 203
TK ALK 1116
CMGC CDK2 4
TK FGFR2 481
TK IGF1R 999
TK INSR 1023
TK MERTK 587
Other NEK7 34
TK RET 724
TK ZAP70 338
-THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-RITE-MQQVEAFL-R-EGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR-----SP-----------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI-LD--REYYSVQQHRHARLPVKWMALESLQ-TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCP----------------------------DSLYQVMQQCWEADPAVRPTFRVLV----GEV--
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDELDFL-M-EALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR-----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I----
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH-TENK-----LYLVFEFLHQ-DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF--GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-S-EMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLR-----ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI-NN--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL------
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLR-----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I----
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR-----SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL------
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLDNSS-QREIEEFL-S-EAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL-----YSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI-YS--GDYY--RQGRIAKMPVKWIAIESLA-DRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL----------------------------DELYEIMYSCWRTDPLDRPTFSVLRLQ--L----
----FRIEKKIGRGQFSEVYRAACL-------LDGVPVALKKVQIFDLMDAK--ARADCIKEIDLLKQL-NHPNVIKYYASFI-EDNE-----LNIVLELADAGDLSRMIKHFKKQKR-------------------------LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITA---TGVVKLGDLGLGRFF--SSKTTAA--HS---LVGTPYYMSPERIH-ENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD-KMNLYSLCKKIEQCDYPPLPSDHYS------------------------EELRQLVNMCINPDPEKRPDVTYV------YDVA
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV-YE--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QGTE-KADTEEMM-R-EAQIMHQL-DNPYIVRLIGVCQ--AEA-----LMLVMEMAGGGPLHKFLV-----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGAD--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M----
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