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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK2 203
CMGC CDK2 4
CAMK CHEK2 220
Other PLK1 53
TK PTK2B 425
Other TTK 525
--YEVLYTIGTGSYGRCQKIRRK---SDGKILVWKELDYGSMTEAE--KQMLVS------EVNLLREL-K-HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQ--YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARIL--NHDTSFAKT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I
--FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGV--PSTAIR------EISLLKEL-N-HPNIVKLLDVIHT--ENKLYLVFEFLHQ-DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
YI--MSKTLGSGACGEVKLAFER---KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL-N-HPCIIKIKNFF-D--AEDYYIVLELMEGGELFDKVV----GNK--RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
YV--RGRFLGKGGFAKCFEISDA---DTKEVFAGKIVPKSLLLKPH--QREKMS-----MEISIHRSL-A-HQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHK----RRK--ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNEDLEV---KIGDFGLATKV--EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
-V-VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCK-KDCT-LDNKEKFM-S------EAVIMKNL-D-HPHIVKLIGIIE---EEPTWIIMELYPYGELGHYLE-----RNKNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVASPECV---KLGDFGLSRYI--E--DEDYYKASVTRLPIKWMSPESIN-----------FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP----------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L-
--YSILKQIGSGGSSKVFQVLNE---KKQ-IYAIKYVNLEEADNQT--LDSYRN------EIAYLNKLQQHSDKIIRLYDYEIT--DQYIYMVMECGNI-DLNSWLK----KKK--SIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV-DGML---KLIDFGIANQMQPDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV-
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