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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE OXSR1 203
CAMK CHEK2 220
TK EGFR 712
TK ERBB3 709
TK HCK 241
TK LCK 245
TK SRC 270
--YELQEVIGSGATAVVQAAYCA----PKKEKVAIKRINLEKCQTSM--DE-LLK------EIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG---VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV---QIADFGVSAFLAT-GGDITRNKVRKT---FVGTPCWMAPEVME--QVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE--MLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF--
YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV--------GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-------LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----EKALDLVKKLLVVDPKARFTTEEALRHPWL--
-F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATS-PKANKEIL-D------EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR---------EH-KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV---KITDFGLAKLL--G---A--EEKEYHAEGGKVPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT-----------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-L-RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIE-DKSG-RQSFQAVT-D------HMLAIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVR---------QH-RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQV---QVADFGVADLL--P---P--DDKQLLYSEAKTPIKWMALESIH---FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICT-----------IDVYMVMVKCWMIDENIRPTFKELANE--F--
--LKLEKKLGAGQFGEVWMATYN-----KHTKVAVKTMK-PGSM-SV--EAFL-A------EANVMKTLQHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLK---------SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC---KIADFGLARVI------E--DNEYTAREGAKFPIKWTAPEAIN---FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP-----------EELYNIMMRCWKNRPEERPTFEYIQSV--L--
--LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-QGSM-SP--DAFL-A------EANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK---------TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC---KIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-PGTM-SP--EAFL-Q------EAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK---------GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
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