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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other AURKA 133
CMGC CDK2 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
AGC GRK6 186
CAMK MAPKAPK2 64
Other NEK2 8
CAMK PASK 999
AGC PDPK1 82
STE STK24 24
Other TTK 525
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLLKKV-S-SGFSGVIRLLDWFER----PDSFVLILERPEPVQDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM-----------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-R-HPN--ILRLYGYFHD----ATRVYLILEYAPLG-TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN----TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-N-HPN--IVKLLDVIHT----ENKLYLVFEFLHQ--DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-N-HPC--IIKIKNFF-D----AEDYYIVLELMEGG-ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRG-GPN--IITLADIVKDP--VSRTPALVFEHVNNT-DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
---YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSILKEI-Q-HPN--VITLHEVYEN----KTDVILILELVAGG-ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFL-GD----TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-N-SRF--VVSLAYAYET----KDALCLVLTLMNGG-DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH---VPEGQTIKGRVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIAGQSPFQ-QR-KKKIKREEVERLVK-EVPEEYSER--FS------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELHWRASQ-CPH--IVRIVDVYENLYAGRKCLLIVMECLDGG-ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-----------
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLLREL-K-HPN--IVRYYDRIIDR--TNTTLYIVMEYCEGG-DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCALMPPFT-AF----SQKELAGKIREGKFRRIPYRY---S------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I----------
---YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEK-VLEDCWI-EDPKLGKVTLEIAILSRV-E-HAN--IIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFID----RHPRLDEPLASYIFRQLVSAVGYLRLK-----DIIHRDIKDENIVIA-EDFTI----KLIDFGSAAY---LERGKLFYTFCGTIEYCAPEVLM----------GNPYRGPELEMWSLGVTLYTLVFEENPFC-EL------EETVEAAIHPPYLVS--------------------------------------KELMSLVSGLLQPVPERRTT-----LEKLVTDPWV-----------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-D-HPF--FVKLYFTFQD----DEKLYFGLSYAKNG-ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVAGLPPFR-AG----NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVLSQC-D-SPY--VTKYYGSYLK----DTKLWIIMEYLGGG-SALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELARGEPPHS-EL-HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
---YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEE-ADNQTLD-SYRN------EIAYLNKLQQHSDK--IIRLYDYEIT----DQYIYMVMECGNI--DLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-QI---INQISKLHAIIDPNHEIEFPDIPE--------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV-----------
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