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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK1 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CAMK CHEK2 220
CAMK DAPK1 13
Other EIF2AK2 267
TK FGFR1 478
TK FGFR2 481
AGC GRK6 186
CMGC GSK3B 56
TK HCK 241
TK INSR 1023
TKL IRAK4 186
CMGC MAPK12 27
CAMK MAPKAPK2 64
Other NEK2 8
AGC PDPK1 82
Other PLK4 12
AGC PRKCI 245
TK PTK2 422
STE STK24 24
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLKPH--Q-R-EKMS-----MEISIHRSL--AHQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLL-ELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GK-PPFETS---------CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--E-H-QLRR------EVEIQSHL--RHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVY-RELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN---------TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
---YELCEVIGKGPFSVVRRCINR-------ETGQQFAVKIVDVAK-FTSSP--G-L-STEDL---KREASICHML--KHPHIVELLETYSS-----------------------------DGMLY--MVFEFMDGA--DLCFEIVKR-ADAGF-----------------VYSEAVASHYMRQILEALRYCHDN-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL---GESGLVAGG---RVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLS-GC-LPFYGT----------KERLFEGIIKGKYKMNPRQWSHIS------------------------ESAKDLVRRMLMLDPAERIT------VYEALNHPWL-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--P-S-TAIR------EISLLKEL--NHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLK-KFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
-YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKRK-FAIGS--A-R-EADPALNVETEIEILKKL--NHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELF-DKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GY-PPFSEH--------RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
---YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKRR-TKSSR--R-G-VSREDI--EREVSILKEI--QHPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELF-DFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK----IDFGNEFKN---IFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GA-SPFLGD---------TKQETLANVSAVNYEFEDEYFSNTS------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
--F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYNN-EKAER----------------EVKALAKL--DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLE-QWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS----LKNDGKRTR---SKGTLRYMSPEQIS---SQDYGKEVDLYALGLILAELLH-VCDTAFET-------------SKFFTDLRDGIISDIFDK-----------------------------KEKTLLQKLLSKKPEDRPN------TSEILR----TLT--------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLS-D-LI-S------EMEMMKMIG-KHKNIINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLR-EYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVT-EDNVM----KIADFGLARDI-H-H--IDYYKKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGG-SPYPGV------PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLS-D-LV-S------EMEMMKMIG-KHKNIINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLR-EYLR-----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVT-ENNVM----KIADFGLARDI-N-N--IDYYKKTTNGRLPVKWMAPEALF---DRVYTHQSDVWSFGVLMWEIFTLGG-SPYPGI------PVEELFKLLKEGHRMDKPANCT------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
--F-RQYRVLGKGGFGEVCACQVR-------ATGKMYACKKLEKKR-IKKRK--G-E-AMAL-----NEKQILEKV--NSRFVVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLK-FHIYH--MGQA-----------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH----VPEGQTIKG---RVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIA-GQ-SPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFKNR----------------ELQIMRKL--DHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA----RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM-SV--E-A-FL-A------EANVMKTL--QHDKLVKLHAVVT------------------------------KEPIY--IITEFMAKG--SLL-DFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVS-ASLVC----KIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAIN---FGSFTIKSDVWSFGILLMEIVTYGR-IPYPGM------SNPEVIRALERGYRMPRPENCP------------------------------EELYNIMMRCWKNRPEERPT------FEYIQSV--L-----------
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERI-E-FL-N------EASVMKGF--TCHHVVRLLGVVSK-----------------------------GQPTL--VVMELMAHG--DLK-SYLR-----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVA-HDFTV----KIGDFGMTRDI-Y-E--TDYYRKGGKGLLPVRWMAPESLK---DGVFTTSSDMWSFGVVLWEITSLAE-QPYQGL------SNEQVLKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPT------FLEIVNLL-------------
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMV-DITTE--ELK-QQFD-----QEIKVMAKC--QHENLVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLL-DRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE-KFAQTVMTSR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GL-PAVDEH------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ--------
---YRDLQPVGSGAYGAVCSAVDG-------RTGAKVAIKKLYRPF-QSELF--A-K-RAYR------ELRLLKHM--RHENVIGLLDVFTPDET-----------------------LDDFTDFY--LVMPFMGT---DLG-KLMK-----HE-----------------KLGEDRIQFLVYQMLKGLRYIHAA-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR------QADSEMTG---YVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFKGS------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AGEALAHPYF-----------
KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDCP-KAR-----------R------EVELHWRA-SQCPHIVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELF-SRIQD--RGDQ-----------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE----TTSHNSLTT---PCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GY-PPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
---YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYGS-MTEAE--K-Q-MLVS------EVNLLREL--KHPNIVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLA-SVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL---NHDTSFAKT---FVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LM-PPFTAF---------SQKELAGKIREGKFRRIPYRY---S------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRH-IIKEN--K-VPYVTR------ERDVMSRL--DHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELL-KYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG---------NEYLIFQKIIKLEYDFPEKFF----------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
--F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKKA-MYKAG--M-V-QRVQ-----NEVKIHCQL--KHPSILELYNYFED-----------------------------SNYVY--LVLEMCHNG--EMN-RYLK---NRVK-----------------PFSENEARHFMHQIITGMLYLHSH-----GILHRDLTLSNLLLT-RNMNI----KIADFGLATQL---KMPHEKHYT---LCGTPNYISPEIAT---RSAHGLESDVWSLGCMFYTLLI-GR-PPFDTD---------TVKNTLNKVVLADYEMPSFLS----------------------------IEAKDLIHQLLRRNPADRLS------LSSVLDHPFM-----------
--F-DLLRVIGRGSYAKVLLVRLK-------KTDRIYAMKVVKKEL-VNDDE--D-I-DWVQ-----TEKHVFEQA-SNHPFLVGLHSCFQT-----------------------------ESRLF--FVIEYVNGG--DLM-FHMQ----RQR-----------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG---LRPGDTTST---FCGTPNYIAPEILR---GEDYGFSVDWWALGVLMFEMMA-GR-SPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS----------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVRE-K-FL-Q------EALTMRQF--DHPHIVKLIGVIT------------------------------ENPVW--IIMELCTLG--ELR-SFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVS-SNDCV----KLGDFGLSRYM---E--DSTYYKASKGKLPIKWMAPESIN---FRRFTSASDVWMFGVCMWEILMHGV-KPFQGV------KNNDVIGRIENGERLPMPPNCP------------------------------PTLYSLMTKCWAYDPSRRPR------FTELKAQL-------------
---FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLEE-AEDEI--E-D-IQ-Q------EITVLSQC--DSPYVTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SAL-DLLE-----PG-----------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL---TDTQIKRNT---FVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELAR-GE-PPHSEL------HPMKVLFLIPKNNPPTLEGNYS------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI-----------
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