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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK RET 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK KIT 589
TKL MAP3K7 36
TK MERTK 587
TK PTK2 422
TK SRC 270
STE STK24 24
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACSQDGP-----LLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG----------------------------------------------------GSRNSSSLDHPDE-RALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARNILVAE---GR-KMKISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI--PPERLFNLLKTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL--
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTREPP-----FYIITEFMTYGNLLDYLR-EC--------------------------------------------------------------------------NR-QEVNAVVLLYMATQISSAMEYLEKKN---FIHRDLAARNCLVGE---NH-LVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI--DLSQVYELLEKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EV-CS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSLQSLP-----RFILLELMAGGDLKSFLR-ETRP---------------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEENH---FIHRDIAARNCLLTCPGPGR-VAKIGDFGMARDIYR--ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK--SNQEVLEFVTSGGRMDPPKNCP--GPVYRIMTQCWQHQPEDRPNFAIILER--I
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFHDATR-----VYLILEYAPLGTVYRELQKLS------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKR---VIHRDIKPENLLLGS---AG-ELKIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN-----TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
-LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PS-AH-LTEREALM-SELKVLSYLGNHMNIVNLLGACTIGGP-----TLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LALDLEDLLSFSYQVAKGMAFLASKN---CIHRDLAARNILLTH---GR-ITKICDFGLARDIKN--DSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM-PVDSKFYKMIKEGFRMLSPEHAP--AEMYDIMKTCWDADPLKRPTFKQIVQL--I
-IEVEEVVGRGAFGVVCKAKWR-------AKDVAIKQIE-----S-ESERKAFI-VELRQLSRV-NHPNIVKLYGACL--NP-----VCLVMEYAEGGSLYNVLH-GA--------------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA---GGTVLKICDFGTACDI-------QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP--KPIESLMTRCWSKDPSQRPSMEEIVKI--M
L-ILGKILGEGEFGSVMEGNLK--QEDGTSLKVAVKTMKLDN-SS-QREIEEFL-SEAACMKDF-SHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLL-YSRL----------------------------------------------------------------------ETGP-KHIPLQTLLKFMVDIALGMEYLSNRN---FLHRDLAARNCMLRD---DM-TVCVADFGLSKKIYS--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGV--QNHEMYDYLLHGHRLKQPEDCL--DELYEIMYSCWRTDPLDRPTFSVLRLQ--L
-IELGRCIGEGQFGDVHQGIYM--SPENPALAVAIKTCK-NC-TS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT-ENP-----VWIIMELCTLGELRSFLQ-VR---------------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLESKR---FVHRDIAARNVLVSS---ND-CVKLGDFGLSRYM-E--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGV--KNNDVIGRIENGERLPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL--
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-EEP-----IYIVTEYMSKGSLLDFLK-GE--------------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANILVGE---NL-VCKVADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM--VNREVLDQVERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L
-FTKLEKIGKGSFGEVFKGIDN-----RTQKVVAIKIIDLEE-AEDEI--EDIQ-QEITVLSQC-DSPYVTKYYGSYLKDTK-----LWIIMEYLGGGSALDLLE-PG------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEK---KIHRDIKAANVLLSE---HG-EVKLADFGVAGQL-TDTQIKRNT---FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAR-GEPPHSEL--HPMKVLFLIPKNNPPTLEGNYS--KPLKEFVEACLNKEPSFRPTAKELLKHKFI
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