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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA5 203
CMGC CDK2 4
CAMK CHEK2 220
CAMK DAPK1 13
TK ZAP70 338
----FELLKVLGTGAYGKVFLVRKISGH--DTGKLYAMKVLKKATIVQKA--KTTEHTR----TERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLS--QRE--RFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHV----VLTDFGLSKEF--VADETERAYS---FCGTIEYMAPDIVR-GGDSGHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISRRILKSEPPYPQEMS--------------------------ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF
----FQKVEKIGEGTYGVVYKARN---K--LTGEVVALKKIRLDTETEGV--PSTAIR------EISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
--YI--MSKTLGSGACGEVKLAFE---R--KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL-NHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV--GNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL
----YDTGEELGSGQFAVVKKCRE---K--STGLQYAAKFIKKRRTKSSR--RGVSREDI--EREVSILKEI-QHPNVITLHEVYENKTDVILILELVAGGELFDFLA--EKE--SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK----IDFGNEFKN---IFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GASPFLGD----TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI
LIAD----IELGCGNFGSVRQGVY---RMRKKQIDVAIKVLK-QGTE-KADTEEMM-R------EAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLV---GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA----KISDFGLSKALGA-D--DSYYTARSAGKWPLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFIEQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M
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