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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK SYK 203
TK CSF1R 582
TK ITK 363
TK LCK 245
TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE---LRL
---LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE-KEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY-IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL---
---LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIREGAMSE---EDFIEEAEVMMKL-SHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV-LDDQY-TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENR-SNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQL---
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQGSMSP---DAFLAEANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEY-TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
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