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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other TTK 203
CMGC CDK2 4
CAMK DAPK1 13
Other NEK2 8
AGC PDPK1 82
CAMK PIM1 38
AGC RPS6KA1 62
STE STK24 24
-YSILKQIGSGGSSKV---FQVLNEKKQ-IYAIKYVNLEEADNQTLD-SYRN----EIAYLNKLQQHSDK--IIRLYDYEIT--DQYIYMVMECGNI--DLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV-----------
-FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDTETEGVPS-TAIR----EISLLKEL-N-HPN--IVKLLDVIHT--ENKLYLVFEFLHQ--DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRRTKSSRRG-VSREDIEREVSILKEI-Q-HPN--VITLHEVYEN--KTDVILILELVAGG-ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLSGASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-YEVLYTIGTGSYGRC---QKIRRKSDGKILVWKELDYGSMTEAEKQ-MLVS----EVNLLREL-K-HPN--IVRYYDRIIDRTNTTLYIVMEYCEGG-DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCALMPPFTAF---SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I----------
F-KFGKILGEGSFSTV---VLARELATSREYAIKILEKRHIIKENKVPYVTR----ERDVMSRL-D-HPF--FVKLYFTFQD--DEKLYFGLSYAKNG-ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVAGLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-YQVGPLLGSGGFGSV---YSGIRVSDNLPVAIKHVEKDRISDWGEL-PNGTRVPMEVVLLKKV-S-SGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM-----------
-FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKM----ERDILADV-N-HPF--VVKLHYAFQT--EGKLYLILDFLRGG-DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLTGSLPFQGK---DRKETMTLILKAKLGMPQFLS--------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
-FTKLEKIGKGSFGEV---FKGIDNRTQKVVAIKIIDLEEAEDEIED-IQ-Q----EITVLSQC-D-SPY--VTKYYGSYLK--DTKLWIIMEYLGGG-SALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
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