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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
Summary of query kinase
Query kinase
AURKC (
Q9UQB9
)
Kinase group
Other
Number of conformation types
0
Number of structural templates
118 (
Total 134 inhibitors
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
72
2F4JA_VX6
(ABL1)
Other
VX-680
I
110
109
134
A
2F4JA_VX6
(ABL1)
Other
VX-680
I
110
109
134
110
109
134
A
2XYNA_VX6
(ABL2)
Other
VX-680
I
79
101
105
79
101
105
A
3E5AA_VX6
(AURKA)
Other
VX-680
I
57
107
93
57
107
93
A
1U59A_STU
(ZAP70)
Other
staurosporine
I
96
80
114
96
80
114
A
1NVRA_STU
(CHEK1)
Other
staurosporine
I
179
71
79
179
71
79
A
3CKXA_STU
(STK24)
Other
staurosporine
I
176
104
141
176
104
141
A
1NXKA_STU
(MAPKAPK2)
Other
staurosporine
I
110
67
51
110
67
51
A
1XJDA_STU
(PRKCQ)
Other
staurosporine
I
121
101
106
121
101
106
A
1YHSA_STU
(PIM1)
Other
staurosporine
I
78
64
50
78
64
50
A
1YVJA_4ST
(JAK3)
Other
staurosporine
I
96
90
126
96
90
126
A
1PKDA_UCN
(CDK2)
Other
UCN 02
I
195
67
118
195
67
118
A
1Q3DA_STU
(GSK3B)
Other
staurosporine
I
115
71
61
115
71
61
A
2HZ4A_4ST
(ABL1)
Other
staurosporine
I
159
103
156
159
103
156
A
1QPDA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
1AQ1A_STU
(CDK2)
Other
staurosporine
I
195
76
118
195
76
118
A
1QPJA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
1NVQA_UCN
(CHEK1)
Other
UCN 02
I
179
65
79
179
65
79
A
2WIHA_P48
(CDK2)
Other
VX_680
I
111
425
105
111
425
105
A
2XIKA_J60
(STK25)
Other
SU11652
I
59
49
65
59
49
65
A
3KVWA_IRB
(DYRK2)
Other
CI_1040
I
15
36
12
15
36
12
A
1Q41A_IXM
(GSK3B)
Other
INDIRUBIN-3'...
I
9
25
10
9
25
10
A
1UV5A_BRW
(GSK3B)
Other
6-bromoindir...
I
27
37
28
27
37
28
A
2J7TA_274
(STK10)
Other
SU11274
I
66
20
77
66
20
77
A
2BHEA_BRY
(CDK2)
Other
BRY
I
51
31
35
51
31
35
A
2J51A_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2JFLA_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2X81A_ZZL
(AURKA)
Other
MLN8054
I
22
24
64
22
24
64
A
1OI9A_N20
(CDK2)
Other
NU-6086
I
52
80
61
52
80
61
A
3A2CA_PDY
(MAPKAPK2)
Other
6-(4-methoxy...
I
32
39
21
32
39
21
A
1R78A_FMD
(CDK2)
Other
4-alkynyl ox...
I
127
24
97
127
24
97
A
2VTTA_LZD
(CDK2)
Other
pyrazole dia...
I
158
42
111
158
42
111
A
3M2WA_L8I
(MAPKAPK2)
Other
Sunitinib
I
84
90
47
84
90
47
A
2OFUA_1N9
(LCK)
Other
2-aminopyrim...
I
55
215
101
55
215
101
A
2WELA_K88
(CAMK2D)
Other
su6656
I
30
30
15
30
30
15
A
1FGIA_SU1
(FGFR1)
Other
Indolin-2-on...
I
25
71
61
25
71
61
A
1UKIA_537
(MAPK8)
Other
1,9-Pyrazolo...
I
20
4
24
20
4
24
A
3BYOA_AM9
(LCK)
Other
AC1NS8OV
I
28
144
90
28
144
90
A
1AGWA_SU2
(FGFR1)
Other
SU 4984
I
77
81
111
77
81
111
A
1OGUA_ST8
(CDK2)
Other
ST8
I
31
21
34
31
21
34
A
3LXLA_IZA
(JAK3)
Other
Pyridone 6
I
30
11
63
30
11
63
A
2HZIA_JIN
(ABL1)
Other
PD180970
I
90
77
120
90
77
120
A
2J2IB_LY4
(PIM1)
Other
Ruboxistaurin
I
35
89
36
35
89
36
A
2XBAA_571
(ALK)
Other
5-Amido-pyrr...
I
17
55
50
17
55
50
A
1OIYA_N41
(CDK2)
Other
N41
I
33
49
34
33
49
34
A
3C4CA_324
(BRAF)
Other
PLX4720
I
35
5
58
35
5
58
A
2OW3A_BIM
(GSK3B)
Other
LY_333531
I
62
139
51
62
139
51
A
2JEDA_LG8
(PRKCQ)
Other
5-Arylidene-...
I
67
19
87
67
19
87
A
3PA5A_C73
(CHEK1)
Other
2-(Carbamoyl...
I
15
74
20
15
74
20
A
3C4DA_325
(BRAF)
Other
PLX4720
I
35
5
58
35
5
58
A
3IW4A_LW4
(PRKCA)
Other
Sotrastaurin
I
52
119
49
52
119
49
A
2C5NA_CK8
(CDK2)
Other
CK8
I
14
49
26
14
49
26
A
3OCSA_746
(BTK)
Other
CGI1746, 2
I
25
89
76
25
89
76
A
1NVSA_UCM
(CHEK1)
Other
SB218078
I
97
6
53
97
6
53
A
3OG7A_032
(BRAF)
Other
PLX4720
I
35
5
58
35
5
58
A
1XWSA_BI1
(PIM1)
Other
bisindolylma...
I
41
132
36
41
132
36
A
2UUEA_MTZ
(CDK2)
Other
Kinome_636
I
10
5
16
10
5
16
A
2IW8A_4SP
(CDK2)
Other
nu6102
I
30
33
30
30
33
30
A
3PJ3A_04L
(BTK)
Other
Imatinib
II
99
113
134
99
113
134
A
3PIYA_585
(BTK)
Other
R-406
I
93
17
123
93
17
123
A
2IW9A_4SP
(CDK2)
Other
nu6102
I
30
33
30
30
33
30
A
1OPLA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2BIKB_BI1
(PIM1)
Other
bisindolylma...
I
41
132
36
41
132
36
A
2VV9A_IM9
(CDK2)
Other
2vv9
I
19
61
36
19
61
36
A
2JDRA_L20
(AKT2)
Other
A-443654
I
44
255
61
44
255
61
A
2FO0A_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2BILB_BI1
(PIM1)
Other
bisindolylma...
I
41
132
36
41
132
36
A
1ZYSA_199
(CHEK1)
Other
2,4-Diamino-...
I
31
92
52
31
92
52
A
2PZYA_B18
(MAPKAPK2)
Other
carboline an...
I
11
56
15
11
56
15
A
1H1SA_4SP
(CDK2)
Other
nu6102
I
30
33
30
30
33
30
A
2J90A_IZA
(DAPK3)
Other
Pyridone 6
I
40
50
42
40
50
42
A
2G2HA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2I0EA_PDS
(PRKCB)
Other
bisindolylma...
I
41
141
45
41
141
45
B
44
3CD3A_STU
(FES)
Other
staurosporine
I
131
107
138
B
3CD3A_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
1WVYA_STU
(DAPK1)
Other
staurosporine
I
83
23
55
83
23
55
B
3LCSA_STU
(ALK)
Other
staurosporine
I
73
100
109
73
100
109
B
1OKYA_STU
(PDPK1)
Other
staurosporine
I
179
67
109
179
67
109
B
1OKZA_UCN
(PDPK1)
Other
UCN 02
I
179
60
109
179
60
109
B
3BKBA_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
3MIYA_B49
(ITK)
Other
Sunitinib
I
70
74
110
70
74
110
B
1UNHA_IXM
(CDK5)
Other
INDIRUBIN-3'...
I
8
25
10
8
25
10
B
2PE2A_464
(PDPK1)
Other
Indolinone b...
I
134
156
104
134
156
104
B
3AMAA_SKE
(PRKACA)
Other
JNJ-7706621
I
46
26
35
46
26
35
B
2VWUA_7X1
(EPHB4)
Other
Chlorobenzod...
I
77
287
111
77
287
111
B
3H10A_97B
(AURKA)
Other
MLN8054
I
39
88
82
39
88
82
B
3H9OA_9BD
(PDPK1)
Other
Benzo[c][2,7...
I
45
68
71
45
68
71
B
2C6EA_HPM
(AURKA)
Other
HPM
I
44
237
90
44
237
90
B
2X9FA_X9F
(EPHB4)
Other
X9F
I
46
19
86
46
19
86
B
1H00A_FAP
(CDK2)
Other
AC1NAE4F
I
50
94
75
50
94
75
B
2XCKA_MH4
(PDPK1)
Other
MH4
I
46
431
75
46
431
75
B
3EFWA_AK8
(AURKA)
Other
3efw
I
100
59
105
100
59
105
B
2WTWA_ZZL
(AURKA)
Other
MLN8054
I
35
24
70
35
24
70
B
2X6EA_YM4
(AURKA)
Other
6-Bromo-7-{4...
I
4
36
3
4
36
3
B
2XRUA_400
(AURKA)
Other
VX_680
I
33
152
63
33
152
63
B
3NYNA_SGV
(GRK6)
Other
SMR000127424
I
54
7
47
54
7
47
B
1UU8A_BI1
(PDPK1)
Other
bisindolylma...
I
83
189
65
83
189
65
B
2BMCA_MPY
(AURKA)
Other
PHA-680632
I
107
108
107
107
108
107
B
2O2UA_738
(MAPK10)
Other
2-[(2-chloro...
I
9
19
21
9
19
21
B
1UU9A_BI3
(PDPK1)
Other
3-[1-(3-AMIN...
I
83
180
69
83
180
69
B
1PXPA_CK8
(CDK2)
Other
CK8
I
14
49
26
14
49
26
B
2C6IA_DT1
(CDK2)
Other
2c6i
I
27
41
48
27
41
48
B
1UVRA_BI8
(PDPK1)
Other
Ro 31-7549
I
82
181
65
82
181
65
B
2C6OA_4SP
(CDK2)
Other
nu6102
I
23
33
27
23
33
27
B
2VZ6A_FEF
(CAMK2A)
Other
indirubin de...
I
15
3
14
15
3
14
B
3ORZA_BI4
(PDPK1)
Other
bisindolylma...
I
82
178
65
82
178
65
B
2XNEA_ASH
(AURKA)
Other
CAS866405_64_3
I
15
43
70
15
43
70
B
1PF8A_SU9
(CDK2)
Other
SU 9516
I
25
19
33
25
19
33
B
1ZRZA_BI1
(PRKCI)
Other
bisindolylma...
I
52
150
47
52
150
47
B
3OTUA_BI4
(PDPK1)
Other
bisindolylma...
I
82
178
65
82
178
65
B
3PY0A_SU9
(CDK2)
Other
SU 9516
I
25
19
33
25
19
33
B
2XB7A_GUI
(ALK)
Other
NVP-TAE684
I
71
66
107
71
66
107
B
3PY1A_SU9
(CDK2)
Other
SU 9516
I
25
19
33
25
19
33
B
2B7AA_IZA
(JAK2)
Other
Pyridone 6
I
34
12
65
34
12
65
B
1UU3A_LY4
(PDPK1)
Other
Ruboxistaurin
I
71
117
57
71
117
57
B
3L9MA_L9M
(PRKACA)
Other
VX_680
I
37
65
42
37
65
42
B
1UU7A_BI2
(PDPK1)
Other
bisindolylma...
I
82
178
65
82
178
65
E
2
2OG8A_1N8
(LCK)
Other
1N8
II
35
190
69
E
2OG8A_1N8
(LCK)
Other
1N8
II
35
190
69
35
190
69
E
2OFVA_242
(LCK)
Other
2ofv
II
28
181
65
28
181
65