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Example1
Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
7 IRAK1 related diseases
hsa05133
Pertussis
hsa05140
Leishmaniasis
hsa05142
Chagas disease (American trypanosomiasis)
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05162
Measles
hsa05169
Epstein-Barr virus infection
Summary of query kinase
Query kinase
IRAK1 (
P51617
)
Kinase group
TKL
Number of conformation types
0
Number of structural templates
8 (
Total 50 inhibitors
)
Number of IRAK1 related diseases
7 (
hsa05133
hsa05140
hsa05142
hsa05145
hsa05152
hsa05162
hsa05169
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
5
2C0IA_L1G
(HCK)
TKL
A-420983
I
61
269
86
A
2C0IA_L1G
(HCK)
TKL
A-420983
I
61
269
86
61
269
86
A
2H8HA_H8H
(SRC)
TKL
Saracatinib
I
91
255
126
91
255
126
A
2NRUA_T12
(IRAK4)
TKL
Kinome_2780
I
4
13
19
4
13
19
A
2C0OA_L2G
(HCK)
TKL
A-770041
I
41
222
65
41
222
65
A
1Y57A_MPZ
(SRC)
TKL
MPZ
I
42
155
94
42
155
94
B
3
2WKMA_PFY
(MET)
TKL
PHA-665752
I
38
34
98
B
2WKMA_PFY
(MET)
TKL
PHA-665752
I
38
34
98
38
34
98
B
2VWUA_7X1
(EPHB4)
TKL
Chlorobenzod...
I
77
287
111
77
287
111
B
2X9FA_X9F
(EPHB4)
TKL
X9F
I
46
19
86
46
19
86